| (-)-Epigallocatechin Gallate |
Inhibitors |
Diospyros kaki|Myrica rubra|Camellia sinensis|Prunus persica|Punica granatum|Ampelopsis japonica|Rhodiola rosea|Eriobotrya japonica|Morus alba|Ardisia japonica|Portulaca oleracea|Paeonia lactiflora| |
Path=ODC1 pathway|ABCG2 pathway|BCL2 pathway|BAX pathway|CASP3 pathway|PARP1 pathway|AR pathway|PSA pathway|N/A|CDK4 pathway|PCNA pathway|Gen=DNA Methyltransferase,HER2,Telomerase,EGFR,Fatty Acid Synthase|15-hydroxyprostaglandin dehydrogenase [NAD+] - Homo sapiens | ATP-dependent DNA helicase Q1 - Homo sapiens | 4'-phosphopantetheinyl transferase ffp - Bacillus subtilis | Arachidonate 15-lipoxygenase - Homo sapiens | Aldehyde dehydrogenase 1A1 - Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 - Homo sapiens | Lysine-specific demethylase 4D-like - Homo sapiens | DNA-(apurinic or apyrimidinic site) lyase - Homo sapiens | Histone acetyltransferase GCN5 - Homo sapiens | MAP kinase ERK2 - Homo sapiens | Vitamin D receptor - Homo sapiens | DNA polymerase kappa - Homo sapiens | Ubiquitin carboxyl-terminal hydrolase 1 - Homo sapiens | HERG - Homo sapiens | Microtubule-associated protein tau - Homo sapiens | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein - Homo sapiens | Galactokinase - Homo sapiens | Putative fructose-1,6-bisphosphate aldolase - Giardia intestinalis|Beta-secretase 1 - Homo sapiens|Beta-secretase 1 - Homo sapiens | Fucosyltransferase 4 - Homo sapiens | CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase - Homo sapiens | Alpha-(1,3)-fucosyltransferase 7 - Homo sapiens|Hepatocyte growth factor receptor - Homo sapiens | 3-oxoacyl-acyl-carrier protein reductase - Plasmodium falciparum | 6-phosphogluconate dehydrogenase - Homo sapiens | Glucose-6-phosphate 1-dehydrogenase - Saccharomyces cerevisiae S288c | Apoptosis regulator Bcl-2 - Homo sapiens | Heat shock protein HSP 90-beta - Homo sapiens | Enoyl-acyl-carrier protein reductase - Plasmodium falciparum | Fatty acid synthase - Plasmodium falciparum |Org= Rattus norvegicus | Human herpesvirus 1 | Plasmodium falciparum | Human immunodeficiency virus 1 |
Dis=Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Basophilic Leukemia|Breast Cancer|Ductal Adenocarcinoma|Cervical Cancer|Cervical Adenocarcinoma|Non-Hodgkin's Lymphomas|Burkitt’s Lymphoma|Prostate Cancer|Prostate Adenocarcinoma|Uterine Neoplasms|leiomyoma|Gen=DNA Damage |
3D viewer |
Pubchem |
4E1A 4KQR 4KQK 4KQO |
65064 |
989-51-5 |
C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O |
|
458.37000 |
C22H18O11 |
3.097 |
3 |
8 |
197.00 |
4.0 |
33 |
4 |
(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity. |
EGCG |
| (-)-Epigallocatechin Gallate |
kinase_inhibitor |
Diospyros kaki|Myrica rubra|Camellia sinensis|Prunus persica|Punica granatum|Ampelopsis japonica|Rhodiola rosea|Eriobotrya japonica|Morus alba|Ardisia japonica|Portulaca oleracea|Paeonia lactiflora| |
Path=ODC1 pathway|ABCG2 pathway|BCL2 pathway|BAX pathway|CASP3 pathway|PARP1 pathway|AR pathway|PSA pathway|N/A|CDK4 pathway|PCNA pathway|Gen=DNA Methyltransferase,HER2,Telomerase,EGFR,Fatty Acid Synthase|15-hydroxyprostaglandin dehydrogenase [NAD+] - Homo sapiens | ATP-dependent DNA helicase Q1 - Homo sapiens | 4'-phosphopantetheinyl transferase ffp - Bacillus subtilis | Arachidonate 15-lipoxygenase - Homo sapiens | Aldehyde dehydrogenase 1A1 - Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 - Homo sapiens | Lysine-specific demethylase 4D-like - Homo sapiens | DNA-(apurinic or apyrimidinic site) lyase - Homo sapiens | Histone acetyltransferase GCN5 - Homo sapiens | MAP kinase ERK2 - Homo sapiens | Vitamin D receptor - Homo sapiens | DNA polymerase kappa - Homo sapiens | Ubiquitin carboxyl-terminal hydrolase 1 - Homo sapiens | HERG - Homo sapiens | Microtubule-associated protein tau - Homo sapiens | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein - Homo sapiens | Galactokinase - Homo sapiens | Putative fructose-1,6-bisphosphate aldolase - Giardia intestinalis|Beta-secretase 1 - Homo sapiens|Beta-secretase 1 - Homo sapiens | Fucosyltransferase 4 - Homo sapiens | CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase - Homo sapiens | Alpha-(1,3)-fucosyltransferase 7 - Homo sapiens|Hepatocyte growth factor receptor - Homo sapiens | 3-oxoacyl-acyl-carrier protein reductase - Plasmodium falciparum | 6-phosphogluconate dehydrogenase - Homo sapiens | Glucose-6-phosphate 1-dehydrogenase - Saccharomyces cerevisiae S288c | Apoptosis regulator Bcl-2 - Homo sapiens | Heat shock protein HSP 90-beta - Homo sapiens | Enoyl-acyl-carrier protein reductase - Plasmodium falciparum | Fatty acid synthase - Plasmodium falciparum |Org= Rattus norvegicus | Human herpesvirus 1 | Plasmodium falciparum | Human immunodeficiency virus 1 |
Dis=Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Basophilic Leukemia|Breast Cancer|Ductal Adenocarcinoma|Cervical Cancer|Cervical Adenocarcinoma|Non-Hodgkin's Lymphomas|Burkitt’s Lymphoma|Prostate Cancer|Prostate Adenocarcinoma|Uterine Neoplasms|leiomyoma|Gen=Others |
3D viewer |
Pubchem |
4E1A 4KQR 4KQK 4KQO |
65064 |
989-51-5 |
C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O |
|
458.37000 |
C22H18O11 |
3.097 |
3 |
8 |
197.00 |
4.0 |
33 |
4 |
(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity. |
EGCG |
| (-)-Epigallocatechin Gallate |
metabolism compound |
Diospyros kaki|Myrica rubra|Camellia sinensis|Prunus persica|Punica granatum|Ampelopsis japonica|Rhodiola rosea|Eriobotrya japonica|Morus alba|Ardisia japonica|Portulaca oleracea|Paeonia lactiflora| |
Path=ODC1 pathway|ABCG2 pathway|BCL2 pathway|BAX pathway|CASP3 pathway|PARP1 pathway|AR pathway|PSA pathway|N/A|CDK4 pathway|PCNA pathway|Gen=DNA Methyltransferase,HER2,Telomerase,EGFR,Fatty Acid Synthase|15-hydroxyprostaglandin dehydrogenase [NAD+] - Homo sapiens | ATP-dependent DNA helicase Q1 - Homo sapiens | 4'-phosphopantetheinyl transferase ffp - Bacillus subtilis | Arachidonate 15-lipoxygenase - Homo sapiens | Aldehyde dehydrogenase 1A1 - Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 - Homo sapiens | Lysine-specific demethylase 4D-like - Homo sapiens | DNA-(apurinic or apyrimidinic site) lyase - Homo sapiens | Histone acetyltransferase GCN5 - Homo sapiens | MAP kinase ERK2 - Homo sapiens | Vitamin D receptor - Homo sapiens | DNA polymerase kappa - Homo sapiens | Ubiquitin carboxyl-terminal hydrolase 1 - Homo sapiens | HERG - Homo sapiens | Microtubule-associated protein tau - Homo sapiens | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein - Homo sapiens | Galactokinase - Homo sapiens | Putative fructose-1,6-bisphosphate aldolase - Giardia intestinalis|Beta-secretase 1 - Homo sapiens|Beta-secretase 1 - Homo sapiens | Fucosyltransferase 4 - Homo sapiens | CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase - Homo sapiens | Alpha-(1,3)-fucosyltransferase 7 - Homo sapiens|Hepatocyte growth factor receptor - Homo sapiens | 3-oxoacyl-acyl-carrier protein reductase - Plasmodium falciparum | 6-phosphogluconate dehydrogenase - Homo sapiens | Glucose-6-phosphate 1-dehydrogenase - Saccharomyces cerevisiae S288c | Apoptosis regulator Bcl-2 - Homo sapiens | Heat shock protein HSP 90-beta - Homo sapiens | Enoyl-acyl-carrier protein reductase - Plasmodium falciparum | Fatty acid synthase - Plasmodium falciparum |Org= Rattus norvegicus | Human herpesvirus 1 | Plasmodium falciparum | Human immunodeficiency virus 1 |
Dis=Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Basophilic Leukemia|Breast Cancer|Ductal Adenocarcinoma|Cervical Cancer|Cervical Adenocarcinoma|Non-Hodgkin's Lymphomas|Burkitt’s Lymphoma|Prostate Cancer|Prostate Adenocarcinoma|Uterine Neoplasms|leiomyoma|Gen=DNA Damage |
3D viewer |
Pubchem |
4E1A 4KQR 4KQK 4KQO |
65064 |
989-51-5 |
C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O |
|
458.37000 |
C22H18O11 |
3.097 |
3 |
8 |
197.00 |
4.0 |
33 |
4 |
(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity. |
EGCG |
| (-)-Epigallocatechin Gallate |
natural product |
Diospyros kaki|Myrica rubra|Camellia sinensis|Prunus persica|Punica granatum|Ampelopsis japonica|Rhodiola rosea|Eriobotrya japonica|Morus alba|Ardisia japonica|Portulaca oleracea|Paeonia lactiflora| |
Path=ODC1 pathway|ABCG2 pathway|BCL2 pathway|BAX pathway|CASP3 pathway|PARP1 pathway|AR pathway|PSA pathway|N/A|CDK4 pathway|PCNA pathway|Gen=DNA Methyltransferase,HER2,Telomerase,EGFR,Fatty Acid Synthase|15-hydroxyprostaglandin dehydrogenase [NAD+] - Homo sapiens | ATP-dependent DNA helicase Q1 - Homo sapiens | 4'-phosphopantetheinyl transferase ffp - Bacillus subtilis | Arachidonate 15-lipoxygenase - Homo sapiens | Aldehyde dehydrogenase 1A1 - Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 - Homo sapiens | Lysine-specific demethylase 4D-like - Homo sapiens | DNA-(apurinic or apyrimidinic site) lyase - Homo sapiens | Histone acetyltransferase GCN5 - Homo sapiens | MAP kinase ERK2 - Homo sapiens | Vitamin D receptor - Homo sapiens | DNA polymerase kappa - Homo sapiens | Ubiquitin carboxyl-terminal hydrolase 1 - Homo sapiens | HERG - Homo sapiens | Microtubule-associated protein tau - Homo sapiens | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein - Homo sapiens | Galactokinase - Homo sapiens | Putative fructose-1,6-bisphosphate aldolase - Giardia intestinalis|Beta-secretase 1 - Homo sapiens|Beta-secretase 1 - Homo sapiens | Fucosyltransferase 4 - Homo sapiens | CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase - Homo sapiens | Alpha-(1,3)-fucosyltransferase 7 - Homo sapiens|Hepatocyte growth factor receptor - Homo sapiens | 3-oxoacyl-acyl-carrier protein reductase - Plasmodium falciparum | 6-phosphogluconate dehydrogenase - Homo sapiens | Glucose-6-phosphate 1-dehydrogenase - Saccharomyces cerevisiae S288c | Apoptosis regulator Bcl-2 - Homo sapiens | Heat shock protein HSP 90-beta - Homo sapiens | Enoyl-acyl-carrier protein reductase - Plasmodium falciparum | Fatty acid synthase - Plasmodium falciparum |Org= Rattus norvegicus | Human herpesvirus 1 | Plasmodium falciparum | Human immunodeficiency virus 1 |
Dis=Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Basophilic Leukemia|Breast Cancer|Ductal Adenocarcinoma|Cervical Cancer|Cervical Adenocarcinoma|Non-Hodgkin's Lymphomas|Burkitt’s Lymphoma|Prostate Cancer|Prostate Adenocarcinoma|Uterine Neoplasms|leiomyoma|Gen=DNA Damage |
3D viewer |
Pubchem |
4E1A 4KQR 4KQK 4KQO |
65064 |
989-51-5 |
C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O |
|
458.37000 |
C22H18O11 |
3.097 |
3 |
8 |
197.00 |
4.0 |
33 |
4 |
(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity. |
EGCG |
| (-)-Epicatechin gallate |
natural product |
Diospyros kaki|Prunus persica|Rheum officinale|Rheum palmatum|Rheum tanguticum|Camellia sinensis|Crataegus pinnatifida|Cynomorium songaricum|Nelumbo nucifera|Balanophora involucrata|Drechslera avenae|Peltostigma guatemalense|Cerinthe minor| |
Path=ODC1 pathway|Apoptosis regulator Bcl-2 - Homo sapiens |Org= Plasmodium falciparum (isolate FcB1 / Columbia)|3-oxoacyl-acyl-carrier protein reductase - Plasmodium falciparum | 6-phosphogluconate dehydrogenase - Homo sapiens | Glucose-6-phosphate 1-dehydrogenase - Saccharomyces cerevisiae S288c | Fatty acid synthase - Plasmodium falciparum | Enoyl-acyl-carrier protein reductase - Plasmodium falciparum | Beta-secretase 1 - Homo sapiens |Org= Plasmodium falciparum|Dihydrofolate reductase - Homo sapiens | 3-oxoacyl-acyl-carrier protein reductase - Plasmodium falciparum | Enoyl-[acyl-carrier-protein] reductase - Escherichia coli K-12 | MAP kinase p38 alpha - Homo sapiens | Solute carrier organic anion transporter family member 1B1 - Homo sapiens | Apoptosis regulator Bcl-2 - Homo sapiens | Solute carrier organic anion transporter family member 1B3 - Homo sapiens | Death-associated protein kinase 1 - Homo sapiens | Fatty acid synthase - Gallus gallus | Human immunodeficiency virus type 1 reverse transcriptase - Human immunodeficiency virus 1 | Serum albumin - Homo sapiens |Org= Staphylococcus aureus | Plasmodium falciparum | Neofusicoccum luteum | Diplodia seriata | Human immunodeficiency virus 1 |
Dis=Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia|Gen=Others |
3D viewer |
Pubchem |
6DHL |
107905 |
1257-08-5 |
C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O |
|
442.37000 |
C22H18O10 |
3.339 |
3 |
7 |
177.00 |
4.0 |
32 |
4 |
Epigallocatechin gallate (EGCG), also known as epigallocatechin-3-gallate, is the ester of epigallocatechin and gallic acid, and is a type of catechin with anti-inflammatory effects. |
(?)-ECG, (?)-Epicatechin 3-gallate, (?)-Epicatechin-3-O-gallate |
| Tea polyphenol |
natural product |
Diospyros kaki|Myrica rubra|Camellia sinensis|Prunus persica|Punica granatum|Ampelopsis japonica|Rhodiola rosea|Eriobotrya japonica|Morus alba|Ardisia japonica|Portulaca oleracea|Paeonia lactiflora| |
Path=ODC1 pathway|ABCG2 pathway|BCL2 pathway|BAX pathway|CASP3 pathway|PARP1 pathway|AR pathway|PSA pathway|N/A|CDK4 pathway|PCNA pathway|Gen=Others|Gen=DNA Methyltransferase,HER2,Telomerase,EGFR,Fatty Acid Synthase|15-hydroxyprostaglandin dehydrogenase [NAD+] - Homo sapiens | ATP-dependent DNA helicase Q1 - Homo sapiens | 4'-phosphopantetheinyl transferase ffp - Bacillus subtilis | Arachidonate 15-lipoxygenase - Homo sapiens | Aldehyde dehydrogenase 1A1 - Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 - Homo sapiens | Lysine-specific demethylase 4D-like - Homo sapiens | DNA-(apurinic or apyrimidinic site) lyase - Homo sapiens | Histone acetyltransferase GCN5 - Homo sapiens | MAP kinase ERK2 - Homo sapiens | Vitamin D receptor - Homo sapiens | DNA polymerase kappa - Homo sapiens | Ubiquitin carboxyl-terminal hydrolase 1 - Homo sapiens | HERG - Homo sapiens | Microtubule-associated protein tau - Homo sapiens | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein - Homo sapiens | Galactokinase - Homo sapiens | Putative fructose-1,6-bisphosphate aldolase - Giardia intestinalis|Beta-secretase 1 - Homo sapiens|Beta-secretase 1 - Homo sapiens | Fucosyltransferase 4 - Homo sapiens | CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase - Homo sapiens | Alpha-(1,3)-fucosyltransferase 7 - Homo sapiens|Hepatocyte growth factor receptor - Homo sapiens | 3-oxoacyl-acyl-carrier protein reductase - Plasmodium falciparum | 6-phosphogluconate dehydrogenase - Homo sapiens | Glucose-6-phosphate 1-dehydrogenase - Saccharomyces cerevisiae S288c | Apoptosis regulator Bcl-2 - Homo sapiens | Heat shock protein HSP 90-beta - Homo sapiens | Enoyl-acyl-carrier protein reductase - Plasmodium falciparum | Fatty acid synthase - Plasmodium falciparum |Org= Rattus norvegicus | Human herpesvirus 1 | Plasmodium falciparum | Human immunodeficiency virus 1 |
Dis=Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Basophilic Leukemia|Breast Cancer|Ductal Adenocarcinoma|Cervical Cancer|Cervical Adenocarcinoma|Non-Hodgkin's Lymphomas|Burkitt’s Lymphoma|Prostate Cancer|Prostate Adenocarcinoma|Uterine Neoplasms|leiomyoma|Gen=Others |
3D viewer |
Pubchem |
3FNU 3QS1 3KDB |
1287 |
84650-60-2 |
C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O |
|
281.36000 |
C17H19N3O |
0 |
0 |
0 |
197.00 |
0.0 |
33 |
4 |
Tea polyphenols are chemical compounds such as flavanoids and tannins found naturally in tea. Several biological properties have been associated to tea polyphenols (TP), including antioxidant, anti-carcinogenic and antimicrobial activities. |
N/A |
| (-)-Epicatechin gallate |
autophagy |
Diospyros kaki|Prunus persica|Rheum officinale|Rheum palmatum|Rheum tanguticum|Camellia sinensis|Crataegus pinnatifida|Cynomorium songaricum|Nelumbo nucifera|Balanophora involucrata|Drechslera avenae|Peltostigma guatemalense|Cerinthe minor| |
Path=ODC1 pathway|Apoptosis regulator Bcl-2 - Homo sapiens |Org= Plasmodium falciparum (isolate FcB1 / Columbia)|3-oxoacyl-acyl-carrier protein reductase - Plasmodium falciparum | 6-phosphogluconate dehydrogenase - Homo sapiens | Glucose-6-phosphate 1-dehydrogenase - Saccharomyces cerevisiae S288c | Fatty acid synthase - Plasmodium falciparum | Enoyl-acyl-carrier protein reductase - Plasmodium falciparum | Beta-secretase 1 - Homo sapiens |Org= Plasmodium falciparum|Dihydrofolate reductase - Homo sapiens | 3-oxoacyl-acyl-carrier protein reductase - Plasmodium falciparum | Enoyl-[acyl-carrier-protein] reductase - Escherichia coli K-12 | MAP kinase p38 alpha - Homo sapiens | Solute carrier organic anion transporter family member 1B1 - Homo sapiens | Apoptosis regulator Bcl-2 - Homo sapiens | Solute carrier organic anion transporter family member 1B3 - Homo sapiens | Death-associated protein kinase 1 - Homo sapiens | Fatty acid synthase - Gallus gallus | Human immunodeficiency virus type 1 reverse transcriptase - Human immunodeficiency virus 1 | Serum albumin - Homo sapiens |Org= Staphylococcus aureus | Plasmodium falciparum | Neofusicoccum luteum | Diplodia seriata | Human immunodeficiency virus 1 |
Dis=Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia|Gen=Others |
3D viewer |
Pubchem |
6DHL |
107905 |
1257-08-5 |
C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O |
|
442.37000 |
C22H18O10 |
3.339 |
3 |
7 |
177.00 |
4.0 |
32 |
4 |
Epigallocatechin gallate (EGCG), also known as epigallocatechin-3-gallate, is the ester of epigallocatechin and gallic acid, and is a type of catechin with anti-inflammatory effects. |
(?)-ECG, (?)-Epicatechin 3-gallate, (?)-Epicatechin-3-O-gallate |
| (-)-Epigallocatechin Gallate |
bioactive compound |
Diospyros kaki|Myrica rubra|Camellia sinensis|Prunus persica|Punica granatum|Ampelopsis japonica|Rhodiola rosea|Eriobotrya japonica|Morus alba|Ardisia japonica|Portulaca oleracea|Paeonia lactiflora| |
Path=ODC1 pathway|ABCG2 pathway|BCL2 pathway|BAX pathway|CASP3 pathway|PARP1 pathway|AR pathway|PSA pathway|N/A|CDK4 pathway|PCNA pathway|Gen=DNA Methyltransferase,HER2,Telomerase,EGFR,Fatty Acid Synthase|15-hydroxyprostaglandin dehydrogenase [NAD+] - Homo sapiens | ATP-dependent DNA helicase Q1 - Homo sapiens | 4'-phosphopantetheinyl transferase ffp - Bacillus subtilis | Arachidonate 15-lipoxygenase - Homo sapiens | Aldehyde dehydrogenase 1A1 - Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 - Homo sapiens | Lysine-specific demethylase 4D-like - Homo sapiens | DNA-(apurinic or apyrimidinic site) lyase - Homo sapiens | Histone acetyltransferase GCN5 - Homo sapiens | MAP kinase ERK2 - Homo sapiens | Vitamin D receptor - Homo sapiens | DNA polymerase kappa - Homo sapiens | Ubiquitin carboxyl-terminal hydrolase 1 - Homo sapiens | HERG - Homo sapiens | Microtubule-associated protein tau - Homo sapiens | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein - Homo sapiens | Galactokinase - Homo sapiens | Putative fructose-1,6-bisphosphate aldolase - Giardia intestinalis|Beta-secretase 1 - Homo sapiens|Beta-secretase 1 - Homo sapiens | Fucosyltransferase 4 - Homo sapiens | CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase - Homo sapiens | Alpha-(1,3)-fucosyltransferase 7 - Homo sapiens|Hepatocyte growth factor receptor - Homo sapiens | 3-oxoacyl-acyl-carrier protein reductase - Plasmodium falciparum | 6-phosphogluconate dehydrogenase - Homo sapiens | Glucose-6-phosphate 1-dehydrogenase - Saccharomyces cerevisiae S288c | Apoptosis regulator Bcl-2 - Homo sapiens | Heat shock protein HSP 90-beta - Homo sapiens | Enoyl-acyl-carrier protein reductase - Plasmodium falciparum | Fatty acid synthase - Plasmodium falciparum |Org= Rattus norvegicus | Human herpesvirus 1 | Plasmodium falciparum | Human immunodeficiency virus 1 |
Dis=Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Basophilic Leukemia|Breast Cancer|Ductal Adenocarcinoma|Cervical Cancer|Cervical Adenocarcinoma|Non-Hodgkin's Lymphomas|Burkitt’s Lymphoma|Prostate Cancer|Prostate Adenocarcinoma|Uterine Neoplasms|leiomyoma|Gen=DNA Damage |
3D viewer |
Pubchem |
4E1A 4KQR 4KQK 4KQO |
65064 |
989-51-5 |
C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O |
|
458.37000 |
C22H18O11 |
3.097 |
3 |
8 |
197.00 |
4.0 |
33 |
4 |
(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity. |
EGCG |
| (-)-Catechingallate |
natural product |
Diospyros kaki|Vitis vinifera|Scutellaria amoena|Dumortiera hirsuta|Annona cornifolia|Pseudoalteromonas luteoviolacea|Rheum coreanum|Zanthoxylum tetraspermum|Rheum officinale|Rauvolfia vomitoria|Eucalyptus melliodora|Pastinaca sativa|Rheum palmatum|Lepisorus ussuriensis|Rheum tanguticum|Cotyledon secunda|Hypericum laricifolium|Premna odorata|Goniothalamus malayanus|Leathesia nana|Vaccinium oxycoccos|Salvia syriaca|Chaenomeles sinensis|Rumex maritimus|Viguiera incana|Wikstroemia retusa|Astragalus sempervirens|Gnetum latifolium|Caragana aurantiaca|Marrubium anisodon|Blastochloris viridis|Bishovia boliviensis|Calostephane divaricata|Sinularia depressa|Lysimachia mauritiana|Solanum laxum|Acacia adunca|Anacystis montana|Swertia franchetiana|Laurencia spectabilis|Amathia pinnata|Phoebe pittieri|Streptomyces avermitilis|green tea|Adiantum lunulatum|Sabina sargentii|Drechslera avenae|Asterospicularia laurae|Ipomoea digitata|Naucleopsis ternstroemiiflora|Hedysarum connatum|Alstonia spathulata|Artemisia assoana|Helipterum roseum|Peltostigma guatemalense|Nasutitermes ephratae |
Path=ODC1 pathway|Apoptosis regulator Bcl-2 - Homo sapiens |Org= Plasmodium falciparum (isolate FcB1 / Columbia)|3-oxoacyl-acyl-carrier protein reductase - Plasmodium falciparum | 6-phosphogluconate dehydrogenase - Homo sapiens | Glucose-6-phosphate 1-dehydrogenase - Saccharomyces cerevisiae S288c | Fatty acid synthase - Plasmodium falciparum | Enoyl-acyl-carrier protein reductase - Plasmodium falciparum | Beta-secretase 1 - Homo sapiens |Org= Plasmodium falciparum |
Dis=Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia|Gen=Others |
3D viewer |
Pubchem |
6DHL |
6419835 |
130405-40-2 |
C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O |
LSHVYAFMTMFKBA-CTNGQTDRSA-N |
442.09000 |
C22H18O10 |
-3.5057 |
2 |
7 |
177.14 |
11.0 |
32 |
4 |
Green tea catechins as a BACE1 (beta-secretase) inhibitor.|Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.|Mass spectrometry-based systems approach for identification of inhibitors of Plasmodium falciparum fatty acid synthase.|Flavonoids as opioid receptor ligands: identification and preliminary structure-activity relationships.|Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme.|Integrated ligand and structure based studies of flavonoids as fatty acid biosynthesis inhibitors of Plasmodium falciparum. |
(-)-Catechin gallate|130405-40-2|(2S,3R)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate|catechin gallate|UNII-0KT1FO6VO6|ent-Catechin 3-O-gallate|0KT1FO6VO6|CHEMBL129451|CHEBI:76131|(2S,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate)|(2S,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate|(-)-Catechin gallate(CG)|(-)-CATECHINGALLATE|Catechin gallate, (-)-|CCRIS 9303|Catechin gallateCG|(?)-Catechin gallate|AC1O4WEY|(-)-catechin 3-o-gallate|(-)-catechin-3-o-gallate|SCHEMBL4639342|CTK8B7907|DTXSID70156528|MolPort-003-940-604|Benzoic acid, 3,4,5-trihydroxy-, (2S,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl ester|HY-N0356|ZINC8681494|(-)-CG|5561AA|ANW-58915|BDBM50135169|LMPK12020091|MFCD00214258|AKOS016002019|CS-3758|AJ-57906|RT-011852|FT-0664410|ST24034089|KS-00001810|S00277|405C402|Q-100119|(-)-Catechin gallate; 3-(3,4,5-trihydroxybenzoate)|(-)-Catechin gallate, >=98% (HPLC), from green tea|(2S,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chroman-3-yl 3,4,5-trihydroxybenzoate|(2S,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate|3,4,5-Trihydroxy-benzoic acid (2S,3R)-2-(3,4-dihydroxy-phenyl)-5,7-dihydroxy-chroman-3-yl ester|3,4,5-Trihydroxybenzoic Acid (2S,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl Ester|Benzoic acid, 3,4,5-trihydroxy-, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl ester, (2S-trans)-| |
| Gallocatechin Gallate |
natural product |
Diospyros kaki|Myrica rubra|Camellia sinensis|Prunus persica|Punica granatum|Ardisiae japonicae herba|Morus alba|Paeonia lactiflora|Solanum nigrum |
Path=ODC1 pathway|ABCG2 pathway|BCL2 pathway|BAX pathway|CASP3 pathway|PARP1 pathway|AR pathway|PSA pathway|N/A|CDK4 pathway|PCNA pathway|Gen=DNA Methyltransferase,HER2,Telomerase,EGFR,Fatty Acid Synthase|15-hydroxyprostaglandin dehydrogenase [NAD+] - Homo sapiens | ATP-dependent DNA helicase Q1 - Homo sapiens | 4'-phosphopantetheinyl transferase ffp - Bacillus subtilis | Arachidonate 15-lipoxygenase - Homo sapiens | Aldehyde dehydrogenase 1A1 - Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 - Homo sapiens | Lysine-specific demethylase 4D-like - Homo sapiens | DNA-(apurinic or apyrimidinic site) lyase - Homo sapiens | Histone acetyltransferase GCN5 - Homo sapiens | MAP kinase ERK2 - Homo sapiens | Vitamin D receptor - Homo sapiens | DNA polymerase kappa - Homo sapiens | Ubiquitin carboxyl-terminal hydrolase 1 - Homo sapiens | HERG - Homo sapiens | Microtubule-associated protein tau - Homo sapiens | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein - Homo sapiens | Galactokinase - Homo sapiens | Putative fructose-1,6-bisphosphate aldolase - Giardia intestinalis|Beta-secretase 1 - Homo sapiens|Beta-secretase 1 - Homo sapiens | Fucosyltransferase 4 - Homo sapiens | CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase - Homo sapiens | Alpha-(1,3)-fucosyltransferase 7 - Homo sapiens|Hepatocyte growth factor receptor - Homo sapiens | 3-oxoacyl-acyl-carrier protein reductase - Plasmodium falciparum | 6-phosphogluconate dehydrogenase - Homo sapiens | Glucose-6-phosphate 1-dehydrogenase - Saccharomyces cerevisiae S288c | Apoptosis regulator Bcl-2 - Homo sapiens | Heat shock protein HSP 90-beta - Homo sapiens | Enoyl-acyl-carrier protein reductase - Plasmodium falciparum | Fatty acid synthase - Plasmodium falciparum |Org= Rattus norvegicus | Human herpesvirus 1 | Plasmodium falciparum | Human immunodeficiency virus 1 |
Dis=Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Basophilic Leukemia|Breast Cancer|Ductal Adenocarcinoma|Cervical Cancer|Cervical Adenocarcinoma|Non-Hodgkin's Lymphomas|Burkitt’s Lymphoma|Prostate Cancer|Prostate Adenocarcinoma|Uterine Neoplasms|leiomyoma|Gen=DNA Damage |
3D viewer |
Pubchem |
4E1A 4KQR 4KQK 4KQO |
199472 |
4233-96-9 |
C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O |
WMBWREPUVVBILR-NQIIRXRSSA-N |
458.08000 |
C22H18O11 |
-3.966 |
2 |
8 |
197.37 |
12.0 |
33 |
4 |
Effect of anthraquinone derivatives on lipid peroxidation in rat heart mitochondria: structure-activity relationship.|Prolyl endopeptidase inhibitors from green tea.|Protective activity of green tea against free radical- and glucose-mediated protein damage.|Study of non-covalent complexation between catechin derivatives and peptides by electrospray ionization mass spectrometry.|Neutrophil restraint by green tea: inhibition of inflammation, associated angiogenesis, and pulmonary fibrosis.|Tea catechin synergies in inhibition of cancer cell proliferation and of a cancer specific cell surface oxidase (ECTO-NOX). |
(-)-Gallocatechin gallate|4233-96-9|Gallocatechin gallate|(-)-Gallocatechol gallate|UNII-IRW3C4Y31Q|(2S,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxybenzoate|Gallocatechin gallate (Gcg)|IRW3C4Y31Q|CHEMBL264938|(-)-gallocatechin-3-O-gallate|(2S,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate)|(2S,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate|Benzoic acid, 3,4,5-trihydroxy-, 3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester, (2S-trans)-|Gallocatechin gallate, (-)-|CCRIS 9286|Gallocatechol, 3-gallate, (-)-|AC1L57GG|SCHEMBL49461|CHEBI:95002|DTXSID20195144|MolPort-003-941-527|GCG|HY-N0522|ZINC3870413|BDBM50236531|MFCD00214298|AKOS015901852|AC-6044|CS-7698|CC-00450|LS-38400|Q431|Gallocatechol, 3-gallate, (-)- (8CI)|FT-0686614|N1665|N1899|KS-00001839|(-)-Gallocatechin gallate, analytical standard|233G969|C-35363|Q-100471|BRD-K19216856-001-01-9|I14-14169|(-)-Gallocatechin gallate, from green tea, >=98% (HPLC)|(2R,3S)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate|(2S,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate|Benzoic acid,3,4,5-trihydroxy-,(2S,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-ylester| |
| (-)-Epicatechin gallate |
bioactive compound |
Diospyros kaki|Prunus persica|Rheum officinale|Rheum palmatum|Rheum tanguticum|Camellia sinensis|Crataegus pinnatifida|Cynomorium songaricum|Nelumbo nucifera|Balanophora involucrata|Drechslera avenae|Peltostigma guatemalense|Cerinthe minor| |
Path=ODC1 pathway|Apoptosis regulator Bcl-2 - Homo sapiens |Org= Plasmodium falciparum (isolate FcB1 / Columbia)|3-oxoacyl-acyl-carrier protein reductase - Plasmodium falciparum | 6-phosphogluconate dehydrogenase - Homo sapiens | Glucose-6-phosphate 1-dehydrogenase - Saccharomyces cerevisiae S288c | Fatty acid synthase - Plasmodium falciparum | Enoyl-acyl-carrier protein reductase - Plasmodium falciparum | Beta-secretase 1 - Homo sapiens |Org= Plasmodium falciparum|Dihydrofolate reductase - Homo sapiens | 3-oxoacyl-acyl-carrier protein reductase - Plasmodium falciparum | Enoyl-[acyl-carrier-protein] reductase - Escherichia coli K-12 | MAP kinase p38 alpha - Homo sapiens | Solute carrier organic anion transporter family member 1B1 - Homo sapiens | Apoptosis regulator Bcl-2 - Homo sapiens | Solute carrier organic anion transporter family member 1B3 - Homo sapiens | Death-associated protein kinase 1 - Homo sapiens | Fatty acid synthase - Gallus gallus | Human immunodeficiency virus type 1 reverse transcriptase - Human immunodeficiency virus 1 | Serum albumin - Homo sapiens |Org= Staphylococcus aureus | Plasmodium falciparum | Neofusicoccum luteum | Diplodia seriata | Human immunodeficiency virus 1 |
Dis=Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia|Gen=Others |
3D viewer |
Pubchem |
6DHL |
107905 |
1257-08-5 |
C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O |
|
442.37000 |
C22H18O10 |
3.339 |
3 |
7 |
177.00 |
4.0 |
32 |
4 |
Epigallocatechin gallate (EGCG), also known as epigallocatechin-3-gallate, is the ester of epigallocatechin and gallic acid, and is a type of catechin with anti-inflammatory effects. |
(?)-ECG, (?)-Epicatechin 3-gallate, (?)-Epicatechin-3-O-gallate |
| Epicatechin Gallate |
natural product |
Diospyros kaki|Parapiptadenia rigida|Perezia carpholepis|Quercus rubra|Dermolepida albohirtum|Phoenix loureiroi|Blastochloris viridis|Gnetum latifolium|Peltostigma guatemalense|Honorius nutans|Helichrysum chionosphaerum|Gardenia jasminoides|Lysimachia mauritiana|Rauvolfia vomitoria|Melochia tomentosa|Zanthoxylum tetraspermum|Lepisorus ussuriensis|Ilex purpurea|Boronia coerulescens|Nasutitermes ephratae|Aizopsis selskiana|Vitis vinifera|Salvia syriaca|Cotyledon secunda|Chaiturus marrubiastrum|Streptomyces hachijoensis|Balanophora involucrata|Rheum officinale|Dictyopteris acrostichoides|Coccus ilicis|Alstonia spathulata|Nuphar lutea|Gomortega keule|Streptomyces paulus|Albizia myriophylla|Triaenophora rupestris|Carduus tenuiflorus|Justicia paniculata|Sinularia maxima|Anaphalis lactea|Lespedeza tomentosa|Artemisia assoana|Lotus japonicus|Phoebe pittieri|Photinia serratifolia|Keiferia lycopersicella|Wikstroemia retusa|Senna siamea|Glycyrrhiza uralensis|Cinnamomum cassia|Euryops algoensis|Annona cornifolia|Penicillium bilaiae|Petunia integrifolia subsp. inflata|Sabina sargentii|Rhododendron dahuricum|Sinularia depressa|Conoideocrella luteorostrata|Rhynchophorus ferrugineus|Swertia franchetiana|Beilschmiedia anacardioides|Picea mariana|Mandragora autumnalis|Acanthophyllum elatius|Rubia oncotricha|Atylosia trinervia|Phyllanthi fructus|Leptocereus quadricostatus|Balanophora laxiflora|Dillenia indica|Alectoria divergens|Hedysarum connatum|Senegalia catechu|Xyris pterygoblephara|Degenia velebitica|Ipomoea digitata|Acacia adunca|Thalictrum longistylum|Crataegus pinnatifida|Ehretia dicksonii|Chaenomeles sinensis|Oophaga granulifera|Dendrodoris tuberculosa|Quercus robur|Cynomorium songaricum|Euphorbia hirta|Bishovia boliviensis|Iryanthera coriacea|Tanacetum coccineum|Anchusa azurea|Caragana aurantiaca|Nelumbo nucifera|Aristolochia zollingeriana|Lentinus tigrinus|Lupinus corymbosus|Leathesia nana|Laurencia spectabilis|Senecio renardii|Orostachys fimbriata|Elephantopus mollis|Dipsacus azureus|Pieris napi|Benincasa hispida|Eucalyptus melliodora|Rumex maritimus|Orostachys japonicus|Salvia parryi|Vaccinium oxycoccos|Premna odorata|Craspidospermum verticillatum|Calostephane divaricata|Bacillus subtilis|Solanum laxum|Rheum coreanum|Verbascum thapsiforme|Viguiera oblongifolia|Hypericum laricifolium|Ramalina stenospora|Ixeris stolonifera|Viguiera incana|Viburnum urceolatum|Caulerpa peltata|Tagetes filifolia|Streptomyces xanthochromogenes|Amathia pinnata|Polyporus betulinus|Rheum palmatum|Anacystis montana|Virola multinervia|Delphinium nuttallianum|Penicillium shearii|Asterospicularia laurae|Rheum tanguticum|Dalbergia lanceolaria subsp. paniculata|Leucopaxillus gentianeus|Delphinium virgatum|Pinalia stricta|Lupinus verbasciformis|Grangea maderaspatana|Marrubium anisodon|Dumortiera hirsuta|Isaria felina|Aframomum amaniense|Sphaerella rosigena|Nepeta granatensis|Scutellaria amoena|Cephalaria grossheimii|Streptomyces avermitilis|Erythrophleum ivorense|Penicillium paxilli|Stephanitis takeyai|Drechslera avenae|Turpinia ternata|Naja kaouthia|Hypericum ascyron|Bartramia pomiformis|Chaetomium carinthiacum|Iris ensata|Khaya senegalensis|Jacquemontia paniculata|Petasites georgicus|Amphorogyne spicata|Penicillium kapuscinskii|Larix cajanderi|Rosa pomifera|Sextonia rubra|Cinnamomum aromaticum|Adiantum lunulatum|Cereus candicans|Onobrychis arenaria|Astragalus sempervirens|Melaleuca rhaphiophylla|Goniothalamus malayanus|Cedrus libani|Senecio behnii|Pseudoalteromonas luteoviolacea|Litsea pungens|Ovophis okinavensis|Artemisia schimperi|Salvia greggii|Metrodorea nigra|Nama hispidum|Bipolaris heveae|Senecio praecox|Gleichenia quadripartita|Khaya ivorensis|Pastinaca sativa|Camellia sinensis|Naucleopsis ternstroemiiflora|Mitracarpus scaber|Helipterum roseum|Cerinthe minor|Dioscorea japonica |
Path=ODC1 pathway|Apoptosis regulator Bcl-2 - Homo sapiens |Org= Plasmodium falciparum (isolate FcB1 / Columbia)|3-oxoacyl-acyl-carrier protein reductase - Plasmodium falciparum | 6-phosphogluconate dehydrogenase - Homo sapiens | Glucose-6-phosphate 1-dehydrogenase - Saccharomyces cerevisiae S288c | Fatty acid synthase - Plasmodium falciparum | Enoyl-acyl-carrier protein reductase - Plasmodium falciparum | Beta-secretase 1 - Homo sapiens |Org= Plasmodium falciparum|Dihydrofolate reductase - Homo sapiens | 3-oxoacyl-acyl-carrier protein reductase - Plasmodium falciparum | Enoyl-[acyl-carrier-protein] reductase - Escherichia coli K-12 | MAP kinase p38 alpha - Homo sapiens | Solute carrier organic anion transporter family member 1B1 - Homo sapiens | Apoptosis regulator Bcl-2 - Homo sapiens | Solute carrier organic anion transporter family member 1B3 - Homo sapiens | Death-associated protein kinase 1 - Homo sapiens | Fatty acid synthase - Gallus gallus | Human immunodeficiency virus type 1 reverse transcriptase - Human immunodeficiency virus 1 | Serum albumin - Homo sapiens |Org= Staphylococcus aureus | Plasmodium falciparum | Neofusicoccum luteum | Diplodia seriata | Human immunodeficiency virus 1 |
Dis=Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia|Gen=Others |
3D viewer |
Pubchem |
6DHL |
107905 |
1257-08-5 |
C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O |
LSHVYAFMTMFKBA-TZIWHRDSSA-N |
442.09000 |
C22H18O10 |
-3.5057 |
2 |
7 |
177.14 |
11.0 |
32 |
4 |
[The inhibitory effects of catechin derivatives on the activities of human immunodeficiency virus reverse transcriptase and DNA polymerases].|[Inhibitory effect of green tea extract on promotion and related action of TPA].|Effect of anthraquinone derivatives on lipid peroxidation in rat heart mitochondria: structure-activity relationship.|Selective inhibition of steroid 5 alpha-reductase isozymes by tea epicatechin-3-gallate and epigallocatechin-3-gallate.|[The inhibitory effects of epicatechin complex on diethylnitrosamine induced initiation of hepatocarcinogenesis in rats].|Inhibitory effects of crude drug components on the proliferation of cultured human mesangial cells. |
(-)-Epicatechin gallate|1257-08-5|Epicatechin gallate|(-)-Epicatechin-3-O-gallate|L-Epicatechin gallate|(-)-epicatechingallate|(-)-Epicatechin-3-gallate|epicatechin monogallate|(-)-Epicatechin 3-O-gallate|Teatannin|Epicatechol, gallate|UNII-92587OVD8Z|3-O-Galloylepicatechin|3-Gallate(-)-Epicatechol|NSC 636594|(-)-cis-3,3',4',5,7-Pentahydroxyflavane 3-gallate|CHEMBL36327|(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate|ECG|CHEBI:70255|LSHVYAFMTMFKBA-TZIWHRDSSA-N|92587OVD8Z|C22H18O10|epicatechin gallate, (2R-cis)-isomer|Benzoic acid, 3,4,5-trihydroxy-, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl ester, (2R-cis)-|(-)-ECG|(-)-cis-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate|(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate|(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chroman-3-yl 3,4,5-trihydroxybenzoate|(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate|Benzoic acid, 3,4,5-trihydroxy-, (2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl ester|epicatechin-3-O-gallate|epi-Catechin 3-O-gallate|Epicatechol, gallate (6CI)|NSC636594|(-)epicatechingallate|Epicatechin 3-gallate|Spectrum_000314|SpecPlus_000275|(-) epicatechin gallate|Spectrum2_000165|Spectrum3_000246|Spectrum4_001540|Spectrum5_000080|epicatechin gallate (ECG)|(-)-Epicatechin gallate,|AC1L32YN|(-)-Epicatechin 3-gallate|(?)-Epicatechin 3-gallate|3-Galloyl-(-)-epicatechin|SCHEMBL39047|BSPBio_001632|KBioGR_001980|KBioSS_000794|SPECTRUM210238|(-)-Epicatechin-3-gallate,|DivK1c_006371|SPBio_000029|AC1Q5X10|MEGxp0_000810|(-)-epi-Catechin 3-O-gallate|(-)-Epicatechin-3-O-gallate,|CTK8E0233|Epicatechol, 3-gallate, (-)-|KBio1_001315|KBio2_000794|KBio2_003362|KBio2_005930|KBio3_001132|(?)-ECG|3,4,5-Trihydroxy-benzoic acid 2-(3,4-dihydroxy-phenyl)-5,7-dihydroxy-chroman-3-yl ester|Benzoic acid, 3,4,5-trihydroxy-, (2S,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl ester|HY-N0002|ZINC3978503|BDBM50153015|CCG-38376|CE0014|LMPK12020090|MFCD00075936|AKOS015965216|AC-6037|AM84365|CS-3761|MCULE-8110076741|SDCCGMLS-0066549.P001|3-Galloyl-(2R,3R)-(-)-Epicatechin|Epicatechol, 3-gallate, (-)- (8CI)|NCGC00179135-01|AJ-47571|AN-48941|AS-15722|LS-38401|Q429|AB0017581|AX8001457|E0890|ST24033389|257E085|C-22380|SR-05000002675|Q-200002|SR-05000002675-1|BRD-K50660797-001-01-0|BRD-K50660797-001-03-6|(-)-Epicatechin gallate, >=98% (HPLC), from green tea|UNII-T432289GYZ component LSHVYAFMTMFKBA-TZIWHRDSSA-N|Epicatechin gallate, primary pharmaceutical reference standard|(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate|(-)-cis-3,3 inverted exclamation marka,4 inverted exclamation marka,5,7-Pentahydroxyflavane 3-gallate|(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-1-benzopyran-3-yl 3,4,5-trihydroxybenzoate|3,4,5-Trihydroxy-benzoic acid (2R,3R)-2-(3,4-dihydroxy-phenyl)-5,7-dihydroxy-chroman-3-yl ester|3,4,5-Trihydroxybenzoic Acid (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl Ester|Benzoic acid, 3,4,5-trihydroxy-, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7- dihydroxy-2H-1-benzopyran-3-yl ester, (-)-cis-|NCGC00179135-03!(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate| |
| 4-Phospho-D-Erythronate |
natural product |
Mus musculus | Escherichia coli |
6-phosphogluconate dehydrogenase - Homo sapiens | 6-phosphogluconate dehydrogenase, decarboxylating - Ovis aries |
|
3D viewer |
Pubchem |
2BET |
449304 |
57229-25-1 |
C(C(C(C(=O)O)O)O)OP(=O)(O)O |
ZCZXOHUILRHRQJ-PWNYCUMCSA-N |
216.00000 |
C4H9O8P |
-1.7524 |
8 |
5 |
154.33 |
10.0 |
13 |
0 |
Analysis of and function predictions for previously conserved hypothetical or putative proteins in Blochmannia floridanus.|Thermodynamic characterization of substrate and inhibitor binding to Trypanosoma brucei 6-phosphogluconate dehydrogenase.|Crystal structures of PI3K-C2alpha PX domain indicate conformational change associated with ligand binding.|Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase.|Enediol mimics as inhibitors of the D-arabinose 5-phosphate isomerase (KdsD) from Francisella tularensis. |
4-Phospho-D-erythronate|4-phosphoerythronate|4-phospho-D-erythronic acid|4-Phospho D-Erythronate|57229-25-1|4-O-phosphono-D-erythronic acid|CHEBI:49003|(2R,3R)-2,3-dihydroxy-4-(phosphonooxy)butanoic acid|2bet|AC1L9MYX|SCHEMBL420471|CHEMBL1160945|CTK1E1186|DTXSID70332305|DER|ZINC3869897|AKOS030570437|DB03108|FT-0673861|C03393|(2R,3R)-2,3-dihydroxy-4-phosphonooxybutanoic acid|R-(R*,R*)-2,3-Dihydroxy-4-(phosphonooxy)butanoic Acid|Butanoic acid, 2,3-dihydroxy-4-(phosphonooxy)-, (2R,3R)-| |
| (-)-Epigallocatechin Gallate |
anticancer |
Diospyros kaki|Myrica rubra|Camellia sinensis|Prunus persica|Punica granatum|Ampelopsis japonica|Rhodiola rosea|Eriobotrya japonica|Morus alba|Ardisia japonica|Portulaca oleracea|Paeonia lactiflora| |
Path=ODC1 pathway|ABCG2 pathway|BCL2 pathway|BAX pathway|CASP3 pathway|PARP1 pathway|AR pathway|PSA pathway|N/A|CDK4 pathway|PCNA pathway|Gen=DNA Methyltransferase,HER2,Telomerase,EGFR,Fatty Acid Synthase|15-hydroxyprostaglandin dehydrogenase [NAD+] - Homo sapiens | ATP-dependent DNA helicase Q1 - Homo sapiens | 4'-phosphopantetheinyl transferase ffp - Bacillus subtilis | Arachidonate 15-lipoxygenase - Homo sapiens | Aldehyde dehydrogenase 1A1 - Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 - Homo sapiens | Lysine-specific demethylase 4D-like - Homo sapiens | DNA-(apurinic or apyrimidinic site) lyase - Homo sapiens | Histone acetyltransferase GCN5 - Homo sapiens | MAP kinase ERK2 - Homo sapiens | Vitamin D receptor - Homo sapiens | DNA polymerase kappa - Homo sapiens | Ubiquitin carboxyl-terminal hydrolase 1 - Homo sapiens | HERG - Homo sapiens | Microtubule-associated protein tau - Homo sapiens | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein - Homo sapiens | Galactokinase - Homo sapiens | Putative fructose-1,6-bisphosphate aldolase - Giardia intestinalis|Beta-secretase 1 - Homo sapiens|Beta-secretase 1 - Homo sapiens | Fucosyltransferase 4 - Homo sapiens | CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase - Homo sapiens | Alpha-(1,3)-fucosyltransferase 7 - Homo sapiens|Hepatocyte growth factor receptor - Homo sapiens | 3-oxoacyl-acyl-carrier protein reductase - Plasmodium falciparum | 6-phosphogluconate dehydrogenase - Homo sapiens | Glucose-6-phosphate 1-dehydrogenase - Saccharomyces cerevisiae S288c | Apoptosis regulator Bcl-2 - Homo sapiens | Heat shock protein HSP 90-beta - Homo sapiens | Enoyl-acyl-carrier protein reductase - Plasmodium falciparum | Fatty acid synthase - Plasmodium falciparum |Org= Rattus norvegicus | Human herpesvirus 1 | Plasmodium falciparum | Human immunodeficiency virus 1 |
Dis=Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Basophilic Leukemia|Breast Cancer|Ductal Adenocarcinoma|Cervical Cancer|Cervical Adenocarcinoma|Non-Hodgkin's Lymphomas|Burkitt’s Lymphoma|Prostate Cancer|Prostate Adenocarcinoma|Uterine Neoplasms|leiomyoma|Gen=DNA Damage |
3D viewer |
Pubchem |
4E1A 4KQR 4KQK 4KQO |
65064 |
989-51-5 |
C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O |
|
458.37000 |
C22H18O11 |
3.097 |
3 |
8 |
197.00 |
4.0 |
33 |
4 |
(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity. |
EGCG |
| Tea polyphenol |
bioactive compound |
Diospyros kaki|Myrica rubra|Camellia sinensis|Prunus persica|Punica granatum|Ampelopsis japonica|Rhodiola rosea|Eriobotrya japonica|Morus alba|Ardisia japonica|Portulaca oleracea|Paeonia lactiflora| |
Path=ODC1 pathway|ABCG2 pathway|BCL2 pathway|BAX pathway|CASP3 pathway|PARP1 pathway|AR pathway|PSA pathway|N/A|CDK4 pathway|PCNA pathway|Gen=Others|Gen=DNA Methyltransferase,HER2,Telomerase,EGFR,Fatty Acid Synthase|15-hydroxyprostaglandin dehydrogenase [NAD+] - Homo sapiens | ATP-dependent DNA helicase Q1 - Homo sapiens | 4'-phosphopantetheinyl transferase ffp - Bacillus subtilis | Arachidonate 15-lipoxygenase - Homo sapiens | Aldehyde dehydrogenase 1A1 - Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 - Homo sapiens | Lysine-specific demethylase 4D-like - Homo sapiens | DNA-(apurinic or apyrimidinic site) lyase - Homo sapiens | Histone acetyltransferase GCN5 - Homo sapiens | MAP kinase ERK2 - Homo sapiens | Vitamin D receptor - Homo sapiens | DNA polymerase kappa - Homo sapiens | Ubiquitin carboxyl-terminal hydrolase 1 - Homo sapiens | HERG - Homo sapiens | Microtubule-associated protein tau - Homo sapiens | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein - Homo sapiens | Galactokinase - Homo sapiens | Putative fructose-1,6-bisphosphate aldolase - Giardia intestinalis|Beta-secretase 1 - Homo sapiens|Beta-secretase 1 - Homo sapiens | Fucosyltransferase 4 - Homo sapiens | CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase - Homo sapiens | Alpha-(1,3)-fucosyltransferase 7 - Homo sapiens|Hepatocyte growth factor receptor - Homo sapiens | 3-oxoacyl-acyl-carrier protein reductase - Plasmodium falciparum | 6-phosphogluconate dehydrogenase - Homo sapiens | Glucose-6-phosphate 1-dehydrogenase - Saccharomyces cerevisiae S288c | Apoptosis regulator Bcl-2 - Homo sapiens | Heat shock protein HSP 90-beta - Homo sapiens | Enoyl-acyl-carrier protein reductase - Plasmodium falciparum | Fatty acid synthase - Plasmodium falciparum |Org= Rattus norvegicus | Human herpesvirus 1 | Plasmodium falciparum | Human immunodeficiency virus 1 |
Dis=Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Basophilic Leukemia|Breast Cancer|Ductal Adenocarcinoma|Cervical Cancer|Cervical Adenocarcinoma|Non-Hodgkin's Lymphomas|Burkitt’s Lymphoma|Prostate Cancer|Prostate Adenocarcinoma|Uterine Neoplasms|leiomyoma|Gen=Others |
3D viewer |
Pubchem |
3FNU 3QS1 3KDB |
1287 |
84650-60-2 |
C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O |
|
281.36000 |
|
0 |
0 |
0 |
197.00 |
0.0 |
33 |
4 |
Tea polyphenols are chemical compounds such as flavanoids and tannins found naturally in tea. Several biological properties have been associated to tea polyphenols (TP), including antioxidant, anti-carcinogenic and antimicrobial activities. |
N/A |
| (-)-Epigallocatechin Gallate |
clinical |
Diospyros kaki|Myrica rubra|Camellia sinensis|Prunus persica|Punica granatum|Ampelopsis japonica|Rhodiola rosea|Eriobotrya japonica|Morus alba|Ardisia japonica|Portulaca oleracea|Paeonia lactiflora| |
Path=ODC1 pathway|ABCG2 pathway|BCL2 pathway|BAX pathway|CASP3 pathway|PARP1 pathway|AR pathway|PSA pathway|N/A|CDK4 pathway|PCNA pathway|Gen=DNA Methyltransferase,HER2,Telomerase,EGFR,Fatty Acid Synthase|15-hydroxyprostaglandin dehydrogenase [NAD+] - Homo sapiens | ATP-dependent DNA helicase Q1 - Homo sapiens | 4'-phosphopantetheinyl transferase ffp - Bacillus subtilis | Arachidonate 15-lipoxygenase - Homo sapiens | Aldehyde dehydrogenase 1A1 - Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 - Homo sapiens | Lysine-specific demethylase 4D-like - Homo sapiens | DNA-(apurinic or apyrimidinic site) lyase - Homo sapiens | Histone acetyltransferase GCN5 - Homo sapiens | MAP kinase ERK2 - Homo sapiens | Vitamin D receptor - Homo sapiens | DNA polymerase kappa - Homo sapiens | Ubiquitin carboxyl-terminal hydrolase 1 - Homo sapiens | HERG - Homo sapiens | Microtubule-associated protein tau - Homo sapiens | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein - Homo sapiens | Galactokinase - Homo sapiens | Putative fructose-1,6-bisphosphate aldolase - Giardia intestinalis|Beta-secretase 1 - Homo sapiens|Beta-secretase 1 - Homo sapiens | Fucosyltransferase 4 - Homo sapiens | CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase - Homo sapiens | Alpha-(1,3)-fucosyltransferase 7 - Homo sapiens|Hepatocyte growth factor receptor - Homo sapiens | 3-oxoacyl-acyl-carrier protein reductase - Plasmodium falciparum | 6-phosphogluconate dehydrogenase - Homo sapiens | Glucose-6-phosphate 1-dehydrogenase - Saccharomyces cerevisiae S288c | Apoptosis regulator Bcl-2 - Homo sapiens | Heat shock protein HSP 90-beta - Homo sapiens | Enoyl-acyl-carrier protein reductase - Plasmodium falciparum | Fatty acid synthase - Plasmodium falciparum |Org= Rattus norvegicus | Human herpesvirus 1 | Plasmodium falciparum | Human immunodeficiency virus 1 |
Dis=Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Basophilic Leukemia|Breast Cancer|Ductal Adenocarcinoma|Cervical Cancer|Cervical Adenocarcinoma|Non-Hodgkin's Lymphomas|Burkitt’s Lymphoma|Prostate Cancer|Prostate Adenocarcinoma|Uterine Neoplasms|leiomyoma|Gen=DNA Damage |
3D viewer |
Pubchem |
4E1A 4KQR 4KQK 4KQO |
65064 |
989-51-5 |
C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O |
|
458.37000 |
C22H18O11 |
3.097 |
3 |
8 |
197.00 |
4.0 |
33 |
4 |
(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity. |
EGCG |
| (-)-Epigallocatechin Gallate |
drug repurposing |
Diospyros kaki|Myrica rubra|Camellia sinensis|Prunus persica|Punica granatum|Ampelopsis japonica|Rhodiola rosea|Eriobotrya japonica|Morus alba|Ardisia japonica|Portulaca oleracea|Paeonia lactiflora| |
Path=ODC1 pathway|ABCG2 pathway|BCL2 pathway|BAX pathway|CASP3 pathway|PARP1 pathway|AR pathway|PSA pathway|N/A|CDK4 pathway|PCNA pathway|Gen=DNA Methyltransferase,HER2,Telomerase,EGFR,Fatty Acid Synthase|15-hydroxyprostaglandin dehydrogenase [NAD+] - Homo sapiens | ATP-dependent DNA helicase Q1 - Homo sapiens | 4'-phosphopantetheinyl transferase ffp - Bacillus subtilis | Arachidonate 15-lipoxygenase - Homo sapiens | Aldehyde dehydrogenase 1A1 - Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 - Homo sapiens | Lysine-specific demethylase 4D-like - Homo sapiens | DNA-(apurinic or apyrimidinic site) lyase - Homo sapiens | Histone acetyltransferase GCN5 - Homo sapiens | MAP kinase ERK2 - Homo sapiens | Vitamin D receptor - Homo sapiens | DNA polymerase kappa - Homo sapiens | Ubiquitin carboxyl-terminal hydrolase 1 - Homo sapiens | HERG - Homo sapiens | Microtubule-associated protein tau - Homo sapiens | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein - Homo sapiens | Galactokinase - Homo sapiens | Putative fructose-1,6-bisphosphate aldolase - Giardia intestinalis|Beta-secretase 1 - Homo sapiens|Beta-secretase 1 - Homo sapiens | Fucosyltransferase 4 - Homo sapiens | CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase - Homo sapiens | Alpha-(1,3)-fucosyltransferase 7 - Homo sapiens|Hepatocyte growth factor receptor - Homo sapiens | 3-oxoacyl-acyl-carrier protein reductase - Plasmodium falciparum | 6-phosphogluconate dehydrogenase - Homo sapiens | Glucose-6-phosphate 1-dehydrogenase - Saccharomyces cerevisiae S288c | Apoptosis regulator Bcl-2 - Homo sapiens | Heat shock protein HSP 90-beta - Homo sapiens | Enoyl-acyl-carrier protein reductase - Plasmodium falciparum | Fatty acid synthase - Plasmodium falciparum |Org= Rattus norvegicus | Human herpesvirus 1 | Plasmodium falciparum | Human immunodeficiency virus 1 |
Dis=Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Basophilic Leukemia|Breast Cancer|Ductal Adenocarcinoma|Cervical Cancer|Cervical Adenocarcinoma|Non-Hodgkin's Lymphomas|Burkitt’s Lymphoma|Prostate Cancer|Prostate Adenocarcinoma|Uterine Neoplasms|leiomyoma|Gen=DNA Damage |
3D viewer |
Pubchem |
4E1A 4KQR 4KQK 4KQO |
65064 |
989-51-5 |
C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O |
|
458.37000 |
C22H18O11 |
3.097 |
3 |
8 |
197.00 |
4.0 |
33 |
4 |
(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity. |
EGCG |
| (-)-Epigallocatechin Gallate |
epigenetics |
Diospyros kaki|Myrica rubra|Camellia sinensis|Prunus persica|Punica granatum|Ampelopsis japonica|Rhodiola rosea|Eriobotrya japonica|Morus alba|Ardisia japonica|Portulaca oleracea|Paeonia lactiflora| |
Path=ODC1 pathway|ABCG2 pathway|BCL2 pathway|BAX pathway|CASP3 pathway|PARP1 pathway|AR pathway|PSA pathway|N/A|CDK4 pathway|PCNA pathway|Gen=DNA Methyltransferase,HER2,Telomerase,EGFR,Fatty Acid Synthase|15-hydroxyprostaglandin dehydrogenase [NAD+] - Homo sapiens | ATP-dependent DNA helicase Q1 - Homo sapiens | 4'-phosphopantetheinyl transferase ffp - Bacillus subtilis | Arachidonate 15-lipoxygenase - Homo sapiens | Aldehyde dehydrogenase 1A1 - Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 - Homo sapiens | Lysine-specific demethylase 4D-like - Homo sapiens | DNA-(apurinic or apyrimidinic site) lyase - Homo sapiens | Histone acetyltransferase GCN5 - Homo sapiens | MAP kinase ERK2 - Homo sapiens | Vitamin D receptor - Homo sapiens | DNA polymerase kappa - Homo sapiens | Ubiquitin carboxyl-terminal hydrolase 1 - Homo sapiens | HERG - Homo sapiens | Microtubule-associated protein tau - Homo sapiens | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein - Homo sapiens | Galactokinase - Homo sapiens | Putative fructose-1,6-bisphosphate aldolase - Giardia intestinalis|Beta-secretase 1 - Homo sapiens|Beta-secretase 1 - Homo sapiens | Fucosyltransferase 4 - Homo sapiens | CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase - Homo sapiens | Alpha-(1,3)-fucosyltransferase 7 - Homo sapiens|Hepatocyte growth factor receptor - Homo sapiens | 3-oxoacyl-acyl-carrier protein reductase - Plasmodium falciparum | 6-phosphogluconate dehydrogenase - Homo sapiens | Glucose-6-phosphate 1-dehydrogenase - Saccharomyces cerevisiae S288c | Apoptosis regulator Bcl-2 - Homo sapiens | Heat shock protein HSP 90-beta - Homo sapiens | Enoyl-acyl-carrier protein reductase - Plasmodium falciparum | Fatty acid synthase - Plasmodium falciparum |Org= Rattus norvegicus | Human herpesvirus 1 | Plasmodium falciparum | Human immunodeficiency virus 1 |
Dis=Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Basophilic Leukemia|Breast Cancer|Ductal Adenocarcinoma|Cervical Cancer|Cervical Adenocarcinoma|Non-Hodgkin's Lymphomas|Burkitt’s Lymphoma|Prostate Cancer|Prostate Adenocarcinoma|Uterine Neoplasms|leiomyoma|Gen=DNA Damage |
3D viewer |
Pubchem |
4E1A 4KQR 4KQK 4KQO |
65064 |
989-51-5 |
C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O |
|
458.37000 |
C22H18O11 |
3.097 |
3 |
8 |
197.00 |
4.0 |
33 |
4 |
(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity. |
EGCG |
